Any IMP's relevant, effective, effective, timely therapy, symptomatic and bacteriological treatment lead to a significantly higher frequency and better prevention. Unfortunately, the treatment can lead to antibiotic resistance to pathogens and comments, and has a negative impact on intestines and vaginal flora, so it is very important to immediately appeal to the doctor and properly choose.
European Microbiology and Society of Infectious Diseases (ESCMID) Corporation of American Infectious Diseases (IDSA) Society (IDSA) has been published in 2011 for treatment with non-acute cystitis and pyelonephritis. This document was an invaluable reference in the Imp office. This instruction discusses important factors in choosing optimal treatment:
- the nature of the resistance of uropogenic;
- sensitivity of urpatogenic bacteria for antimicrobial drugs;
- The probability of side effects of antimicrobial drugs.
As for sensitivity, two important facts are recorded in this leadership:
- In recent years, the stability of uropogenic antibiotics increased;
- The nature of the resistance demonstrates serious geographical variability between countries and even the regions.
Thus, recommendations are periodically revived to conduct research, which periodically developed resistance, developing new tools and the advantage of drugs and inefficiency. According to recommendations and recommendations and research, the requirements for medicines for the treatment of non-absolute cystitis are best met with the following items:
- phosphomic;
- nitrofurantine.
The following selection criteria were used: Pharmacokinetics, interaction, stroke, impact on antibiotics, effectiveness, efficiency, side effects, dosage frequency, treatment period, value for the cost.
The study includes the following medications: amoxicillin (with clavanic acid), nitrofurantine, sulfametic, trimtopime, kooktopime, co-trimoxazole, norfloxhazol, norfloxacol and phosphomic trometamol.
Table 1. The first line for the treatment of cystitin
| Substance | Dose | Duration of treatment |
| PhosFomic's TromTamol | 3 g single dose | Single dose (once) |
| Nitrofurantine | 50-100 mg four times a day | 5-7 days |
Phosphone was opened as a new class representative of Phosphone antibiotics in 1969.
Active item: phosphomis. Release form: 1 or 2 packaging packaging, 3 g / bag, granules to solve with 2 g / bag dose.
Uroantiseptics refers to a clinical and an international group for antibiotics (phosphonic acid derivative).
PhosFomycin has a large spectrum bactericidal activity:
- Stafilokocci (Stafilokoccus SPP. );
- Enterococci (Atherococcus SPP. );
- HAEMOPHIDUS SPP;
- Most intestinal grams, including 95, 5% E. coli, expanded spectrum (Blrs) produces lactamases;
- Coli strains that produce sensitive metal-β-lactamine to E. phosphomis;
- Sitrobacterer SPP. ;
- Enterobacter SPP. ;
- Klebsiella SPP. , Klebsiella pnevemmoniae;
- Morganella Morganii;
- Proteus mirabilis;
- Pseudomonas spp. ;
- Serratia SPP.
- TromTamol Fosfomis has not only been identified for the treatment of cystitis, which is not sharp in the form of a dose of only 3 G.
- If you pick up before dinner, the best sucks.
- It reaches a high concentration in the urine and maintains more than 24 hours.
In several studies, the first line was compared to clinical and microbiological effectiveness, other antimicrobials of the first line. Clinical efficiency of a dose (3 g) 91% of the phospace (91% of patients occur). The indicator can be compared to nitrofurantoine (93%), trimetrom-sulfametoxazole (93%) and fluoroquinolons (90%).
Microbiological level of treatment (80%) is lower than 88-94% of comparable antibiotics. However, the latest meta -analiz did not discover the differences between 27 research, phosphhomic and other antibiotics and revealed the following facts:
- PhosFomycin causes significant little negative reactions in pregnant women, including the most important.
- An additional benefit is to treat multiple files microorganisms. Several research in Intro, staphylococcios resisting the phosphome Vanciko showed that it was active in operation for BLRs producing Aureus and gram-negative rods.
- K. Menqionee. Enderobactiaceae is effective in the treatment of the Impin, which causes Terbapenemase (in the dose of 3 g in the dose of 3 g, again).
- Has a minimal side effect on the body. This is shown in women, women, in the areas of the frequent use of phosphome, the sensitivity of E. Coli's sensitivity;
- Ease of single dose mode.
- Acute cystitis (bacterial origin);
- escalation of recurrent cystitis (bacterial origin);
- urethritis (bacterial non-center);
- Bacteriary of pregnant women asymptomatic;
- IMP after transactions;
- Prevention of Impin.
| Treatment of simple acute cystitis | Heavy forms that are repeated / heavy | Prevention of Impin |
| Adults - Once 3. 0 G (1 Package)
Children (under 5) - 2. 0 g once |
Adults - 3. 0 g twice, second after 24 hours | First Technique: 3 hours before the operation / diagnostic procedure 3. 0 g 3 hours ago
Second trick: 24 hours later 24 hours later |
- Follow all the instructions on the label.
- The phosfomycin is usually assigned only in one dose.
- Do not take in large / smaller quantities or longer if they are not appointed by a doctor.
- Can be used after / at the same time.
- PhosFomycin is a powder medicine, should be diluted with water before use. Do not take dry powder without adding water.
- 1/2 cup of cold water, mix a bag of cold water and drink immediately. You can add a little more water to the same glass, shake and drink immediately to ensure a complete dose.
- Do not mix with hot water.
- It's good to spend an night. There will be a longer break between the urine that will ensure a longer presence of the claim and a more effective effect.
- Keep in the original packaging at room temperature and away from heat.
Other instructions:
- Symptoms can not immediately pass immediately after 2-3 days;
- After treatment, there is no symptoms within 3 days, there is no contact with a urologist;
- Before applying the patient, it is recommended to consult a doctor to make sure that the phosphome is an antibiotic suitable for treatment. In addition, urinary analysis may be required before and after this medicine.
Contraindications:
- Children under 5 years of age;
- Allergic reactions to components;
- Heavy kidney failure.
General side effects:
- Heart of nausea, gastric disorder, a light diarrhea;
- headache, dizziness;
- Itching or vaginal discharge (rarely).
It is not recommended simultaneously with a meteklopramid to prevent weakening the movement of metosmomin.
Thus, the convenience of a dose mode related to resistant grams of resistant grams caused by the convenience of a dose mode, both simple, immature, complex and immature, The minimum incendability of the side damage makes the phosphome a useful choice in the treatment of low MVP (cystitis, urethritis).
Active item: nitrofurantine. Form of release: tablets, dosage 100 mg, 50 mg.
It is stated in accordance with the clinical and agricultural group in accordance with antimicrobials.
Nitrofurant's associated with a group of synthetic nitrofurans, first introduced in the form of a microcrystal form. In 1967, the macrokrystallin form was existed with gastrointestinal tolerance.
Currently, there are two main types of nitrofurant: a mixture of macrocrystallic form and microcrystal and macrocrystal forms (25 mg macrocrystal and 75 mg monoidrate). Mixed species in a patented double delivery system were not registered in the Russian Federation and not in circulation.
Mechanisms of nitrofurant's bacterial activity include several sites:
- Inhibition of ribosomal broadcasting;
- damage to bacterial DNA;
- Interference in the cycle of Krebs.
Nitrofurant's relationship is active:
- more than 90% of intestinal strains that cause impin;
- Enterococcus that is resistant to Vancromis;
- Klebsiella SPP. ;
- Proteus spp. ;
- Staphylococci (gold and saprofittic) are generally sensitive.
The resistance of the drug is uncommon, probably due to many areas of the drug. However, the nitrofurantoine of proteus, serratia and pseudomones has natural resistance.
Nitrofurantino, the manufacturer of bacteria can be an additional choice for the treatment of a sharp complex cystitis of bacteria.
Pharmacokinetics. Emilim gets better when eating. Nitrofurant's concentrations in the serum are not defined in a low or standard dose, the content of the prostate gland is not detected. Basically, the concentration of the drug (50 to 250 mg / ml) is secreted in urine with more than 32 mg / ml MPC.
Nitrofurantin, to patients with chopped kidney failure (Kreinin cleanPatients with <60 m / min) should not be appointed, but research observed high efficiency of medicine in patients with 60-30 ml / min.
It is safe for use in pregnant women and children.
Tips: cystitis (bacterial origin) treatment and prevention.
Dosage. This is determined by an urologist based on the severity of the state, term and symptoms of the state.
The usual dose for the adults of cystitis:
- 4 times a day or at least 3 days a day after a week, after the indefinition of urine and at least 3 days a day or at least 3 days a day. Ordinary dose for adults to prevent the cystitis:
- Once off the bed, 50 and 100 mg of 100 mg once. Child dose for cystitis:
- 1 monthly and above: 5-7 mg / kg (up to 400 mg per day) Oral. Ordinary child dose for the prevention of the cititis:
- 1 monthly and larger: 1 to 2 mg / kg / kg / kg / kg per day) Verbally accepted 1-2.
Most experts agree with the recommendation of a 5-day drug for the treatment of acuteless cystitis. The research showed more than 79% to 95% to 79% to 95% of early clinical treatment and more than 79 to 92% of microbiological treatment. The clinic effectiveness of the study of the study of a dose of trimetrom-sulfamethetoxazole (beads), Cypriofloxasin and Trometamol phosphome (monudetamol). However, the speed of microbiological treatment has always been a little favorable for comparative medications.
- Instructions for medication need to follow the recipes and instructions of all doctors.
- Do not use a longer or smaller amount or longer than recommended.
- Nitrofurantin is better to buy food (bioavailability rise).
- It is recommended to observe the setting within the entire specified period. Symptoms can be passed before, but treatment cannot be stopped when the infection is completely eliminated. Doses can increase the risk of further development of infection antibiotic development risk and further development of relapse.
- Nitrofurant's viral infections are not treated in cold or flu.
General side effects:
- headache, dizziness;
- gas formation, gastric disorder;
- Light diarrhea;
- Itching or vaginal discharge.
Very often found:
- watery or bloody diarrhea;
- Sudden pain or anxiety in the chest, breathe, dry cough;
- Difficulty breathing;
- To lose fever, cold, pain in the body, fatigue, inexplicable;
- numbness, tingling or pain in the hands or legs;
- Liver problems - heartbreaking, in the upper part of the stomach, pain, itching, feeling of fatigue, appetite, dark urine, clay, jaundice or eye dressing);
- Lupid syndrome - firing, swollen glands, muscle pain, chest pain, chest pain, vomiting, unusual thoughts or behavior, joint pain or edema.
Serious side effects may be more than the older, long-term patient or weaker people.
Contraindications:
- serious disorders of the excretory function of kidneys;
- kidney failure;
- Oliguria;
- glucose-6-phosphate dehydrogenase deficiency;
- Pregnancy;
- Age to 1 month;
- Allergic reactions to components;
- XN II-III stages;
- cirrhosis;
- chronic hepatitis;
- Acute porphyria;
- lactation.
Pregnancy drug category: (FDA - according to the US Health Agency). This drug is expected to damage the unborn child in the early stages of pregnancy. In the last 2-4 weeks of pregnancy, it is contraindicated.
Nitrofurantin, can penetrate breast milk, is not lactated during lactation.
- The risk of peripheral neuropathy is anemia, diabetics, a violation of a severe mon, electrolyte balance, lack of vitamins B.
- Nitrofurantin, prostatitis treatment, cortical substance of kidneys, the treatment of the purulent paraneprit is not used for treatment. With a pyelonephritis, it is not shown due to the ineffectiveness.
- Nitrofurantin can give unusual results with a certain laboratory glucose (sugar) in the urine.
- Are not compatible with fluororocinones.
- Nitrofurant's antimicrophe's activity, delete, and antacids based on the magnificent acid magnesium.
- Channel secretion, which does not prevent the channel sector, reduces the properties of bactericidate because they increase the toxicity of nitrofurant (the content of the urine).
Nitrofurant's first line in an unpredalized cystitis is considered a therapeutic remedy in the unprecious cystitis:
- The effectiveness of the 5-day course;
- risk of inflicting a side effect and damage to the normal flora of a person;
- Minimum resistance of bacteria;
- Other antimicrobial drugs can be compared.